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NORTH KOREA'S KIM JONG UN EXPRESSES WARM ENCOURAGEMENT FOR OVERSEAS OPERATIONS MILITARY TROOPS CARRYING OUT ORDERS -KCNA

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NORTH KOREA'S KIM JONG UN SAYS ITS MILITARY'S HEROISM WILL NOT ONLY BE SEEN IN THE DEFENSE OF NORTH KOREA BUT ALSO IN OUTPOSTS OF SOCIALIST CONSTRUCTION -KCNA

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Oct 10 (Reuters) – The U.S. Food and Drug Administration on Friday approved labeling changes for Johnson & Johnson and its partner Legend Biotech's blood cancer therapy to include a boxed warning for a potentially fatal gastrointestinal condition. The FDA said it received reports that some patients treated with Carvykti developed a serious gut inflammation called IEC-EC, which in some cases led to life-threatening complications like bowel perforation and sepsis. Reports were received from clinical trials and postmarketing adverse event data, the FDA said. IEC-EC is a form of inflammation of the intestines triggered by the immune system. It was observed weeks to months after CAR-T therapy treatment with Carvykti in both clinical trials and after approval, the regulator said. Symptoms included persistent diarrhea, stomach pain and weight loss, often requiring intensive care and immune-suppressing drugs. Carvykti was first approved in February 2022 and received expanded approval in April 2024 for adults with relapsed or refractory multiple myeloma who had received at least one prior line of therapy. Multiple myeloma is an incurable blood cancer that affects a type of white blood cell called plasma cells, found in the bone marrow. The FDA also updated the "clinical studies" section of the drug's prescribing information to include overall survival data from the late-stage trial. The interim data of the late-stage study showed a statistically significant improvement in survival for patients receiving Carvykti compared to those on standard therapy, with a median follow-up of 33.6 months. Despite the new safety concerns, the FDA said the overall benefit of Carvykti continues to outweigh the risks for its approved use. (Reporting by Siddhi Mahatole in Bengaluru; Editing by Alan Barona)

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WASHINGTON, Oct 10 (Reuters) – U.S. President Donald Trump said on Friday the hostages held by Palestinian militant group Hamas in Gaza are due to "come back" on Monday. Speaking to reporters at the White House, he said there were approximately 28 bodies to be recovered. He said he thought he would be traveling to Cairo and he would later speak to the Israeli Knesset, before returning to the U.S. on Tuesday. (Reporting by Steve Holland and Gram Slattery; Editing by Chris Reese)

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TRUMP: VENEZUELA OPPOSITION LEADER MACHADO CALLED ME

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TRUMP: IT WILL BE A LOT OF PEOPLE

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TRUMP: OTHER THINGS COULD BE ON TABLE FOR EXPORT CONTROLS

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Oct 10 (Reuters) – Complete Solaria Inc: * SUNPOWER REPORTS INDUCEMENT GRANTS IN CONNECTION WITH SUNDER ACQUISITION Source text: Further company coverage:

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(Corrects quote in last paragraph to read 'AI theme') * Trump's tariff threats against China trigger market concerns * S&P 500 and Nasdaq post largest drops since April 10 * AI enthusiasm still seen by some as market's main driver By Chibuike Oguh NEW YORK, Oct 10 (Reuters) – Investor worries that Wall Street's record stock rally would soon fizzle loomed large after tariffs re-emerged as a market risk. U.S. equity markets, fresh off midweek record highs, performed an about-face on Friday after President Donald Trump revived threats to hike tariffs against China, triggering worries that a possible tit-for-tat trade drama between the world's two biggest economies could mark the end of a record-breaking rise in U.S. equities. Trump, who was due to meet Chinese President Xi Jinping in about three weeks in South Korea, canceled the meeting and complained on social media about what he called China's plans to hold the global economy hostage after it dramatically expanded its rare earths export controls on Thursday. TARIFF TALK DRIVES DOWN MARKET Wall Street stocks fell sharply following Trump's comments. The Dow Jones Industrial Average fell 1.90%, the S&P 500 lost 2.71%, and the Nasdaq Composite lost 3.56%. The S&P 500 and the Nasdaq recorded their largest single-day percentage drops since April 10. The selloff raises concerns that high stock market valuations propelled by enthusiasm over artificial intelligence might lead to a significant downturn. The S&P 500 and the Nasdaq hit fresh record highs on Thursday and are up about 11% and 15%, respectively, in 2025. The Dow has gained about 7% year-to-date, all of which has rekindled memories of the late 1990s dotcom bubble that burst in 2000. JPMorgan Chase CEO Jamie Dimon, in a BBC interview on Wednesday, warned of a heightened risk of a significant Wall Street correction within the next six months to two years. "With equities at high valuations, this selloff is a sign of jitters," said Gene Goldman, chief investment officer at Cetera Investment Management. "Everything is priced for perfection, so the uncertainty increases market jitters. All of this adds uncertainty to economic growth." In April, Trump's announcement of what he called Liberation Day tariffs stunned markets and sent investors scrambling, causing S&P 500 companies to shed a combined $2.4 trillion in market value. But some investors say the latest U.S.-China trade tensions are unlikely to significantly change the market trajectory, with AI remaining the driving factor. "This is definitely a significant issue, and it could warrant a pullback but I don't necessarily see it derailing the AI theme that's been driving the market," said James St. Aubin, chief investment officer at Ocean Park Asset Management. (Reporting by Chibuike Oguh in New York; additional reporting by Sinead Carew in New York; Editing by Alden Bentley, Rod Nickel)

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The Los Angeles Chargers have lost two in a row after a promising 3-0 start while the Miami Dolphins lost any momentum they had from a Monday Night Football win over the Jets last Sunday following a disappointing loss at Carolina. Both sides will try to get back on track when they clash on Sunday afternoon in Miami Gardens, Fla. The Chargers (3-2) watched a 10-0 first-quarter lead slip away in what resulted in a 27-10 loss at home against the Washington Commanders. Meanwhile, the Dolphins (1-4) let a 17-0 first-half lead evaporate before losing 27-24 to the Panthers. While Miami's season appears to be fading away following its latest setback, the Chargers still have time to turn their fortunes around if they can snap their two-game skid. Los Angeles continues to deal with injuries to key players, including starting running back Omarion Hampton, who was placed on injured reserve with an ankle injury on Monday. It will keep him sidelined for at least the next four games. Without Hampton, the Chargers will turn to running backs Hassan Haskins and Kimani Vidal to pick up the slack. The Chargers also signed veteran Nyheim Hines to their practice squad. It might not matter much if Los Angeles can't shore up an offensive line ravaged by injuries after losing tackles Rashawn Slater, who is out for the season with a torn patellar tendon, and Joe Alt (high ankle sprain), who missed the team's Week 5 matchup. Pass protection problems compounded the Chargers' issues last week. Justin Herbert was sacked four times by Washington and has taken 16 sacks for the season, which is tied for third-most in the NFL. Costly penalties negating key first downs was another issue in last week's loss. "We're good enough to overcome some, but you need to minimize them," Chargers coach Jim Harbaugh said. "That's an area that we need to get better at." The Dolphins lost Tyreek Hill two weeks ago to a season-ending knee injury, but their passing game had one of its best performances of the season against the Panthers. Tua Tagovailoa, limited in practice Wednesday with thumb and hip issues, threw for 256 yards and three touchdown passes without an interception against the Panthers. He seemed to revive the connection with receiver Jaylen Waddle, who caught a season-high six passes for 110 yards and a touchdown. Tight end Darren Waller, who sat out Wednesday's practice to rest, continued to shine in his second start of the season, catching five passes for 78 yards and a touchdown. The Dolphins' rushing game was virtually non-existent in Week 5 with just 19 yards on the ground. Miami also couldn't slow down Carolina's ground attack, led by Rico Dowdle, who ran for a career-high 206 yards and a touchdown on 23 carries. Dolphins coach Mike McDaniel said Wednesday that his team can't take the Chargers' depleted backfield or weakened offensive line lightly just because less experienced running backs will likely be handling the ball. "Any given week, if you take any foot off the gas, any guy whether you know him or not — I'm not sure if you knew who No. 5 was last week, regardless, you have to tackle him," McDaniel said. "That will be our focus. There's always talented runners on each team or they wouldn't be there. They will stress us and we will see if we're ready for them, or they'll introduce themselves to us in the way we don't want." The Dolphins placed cornerback Cornell Armstrong (hamstring) on IR, and signed safety Jordan Colbert to their active roster and Kendall Sheffield to their practice squad. Linebacker Tyrel Dodson (concussion) and Elijah Campbell (quad) won't suit up Sunday, while offensive lineman Aaron Brewer (pectoral) and cornerback Storm Duck (ankle) are listed as questionable. For the Chargers, Joe Alt (ankle), right tackle Trey Pipkins III (knee), defensive lineman Da'Shawn Hand (groin) and wide receiver Derius Davis (knee) have all been ruled out for Sunday. Offensive lineman Jamaree Salyer (knee), outside linebacker Bud Dupree (hamstring), wide receiver Quentin Johnston (hamstring), fullback/defensive tackle Scott Matlock (ankle) and linebacker Denzel Perryman (ankle) all have questionable tags. –Field Level Media

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