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London (dpa) – University of Cambridge researchers believe they have shown how artificial intelligence (AI) can narrow down who is most at risk of developing breast cancer between two scheduled mammograms. Published by the Radiological Society of North America (RSNA), the team used an AI bot called Mirai to assess around 134,000 mammograms to find cases where supplemental imaging might be needed after a regular screening ended with a negative or no-cancer result. The device generated what the team described as a "generalized risk score" for developing a so-called interval breast cancer – when the disease develops between mammograms – after checking information gleaned from a mammogram, such as tumour features and breast density. "We can use supplemental imaging and adjust screening frequency based on a woman’s breast density and likelihood of developing breast cancer within a short timeframe," said Fiona Gilbert, professor of radiology at the University of Cambridge, explaining where and when the AI tool could be used. The mammograms assessed were from British women aged between 50 and 70, screened between 2014 and 2016. "Interval cancers generally have a worse prognosis compared with screen-detected cancers, because they tend to be either larger or more aggressive," said Gilbert, also an honorary consultant radiologist at Cambridge's Addenbrooke's Hospital. "Identifying women at an increased risk of developing breast cancer is a complex, multifactorial problem," Gilbert said. The researchers said their goal was to more accurately identify the women "most likely to have an interval cancer" while simultaneously reducing the workload around taking supplemental images. The following information is not intended for publication dpa spr coh

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No sleep, hot flushes, brain fog: women can experience a wide range of menopausal symptoms and for some, they can be extremely severe. How far can hormones help handle them? Berlin (dpa) – Myths, uncertainties and long-outdated assumptions mark the menopause like few other areas of medicine and health care. This is particularly true of menopausal hormone therapy, or hormone replacement therapy (HRT), prescribed to help women handle some menopausal symptoms. What to know Menopause – what exactly is it? The menopausal transition describes the change from the reproductive phase of a woman's life to permanent infertility and is associated with significant hormonal changes. Menopause or climacteric are terms used to describe the entire transition phase, which usually lasts 10 to 15 years. The term is often used differently, but in fact "menopause" refers exclusively to the time of the last menstrual period and is determined retrospectively when no period has occurred for twelve months. On average, menopause occurs at the age of 51, by when the supply of eggs created before birth is exhausted. The timing has remained unchanged, even though women today live significantly longer on average and are usually much fitter at 50 than their peers were 50 or 100 years ago. What exactly happens? "Most women think they don't have any menopause symptoms as long as their period comes reasonably on time," says DMG President Katrin Schaudig. However, the first changes in the cycle and symptoms such as mood swings can occur as early as the late 30s or early 40s – the first signs of the onset of the menopause. During perimenopause, usually between the ages of 45 and 50, the cycle becomes increasingly irregular, with intermenstrual bleeding and longer breaks between periods. Fluctuations in both cycle-determining hormones (progesterone and oestrogen) characterise this phase. "These are then spring tides and tsunamis in hormone levels instead of ebb and flow as before in the cycle," says Schaudig. Psychological problems can arise. Towards the end of perimenopause, oestrogen levels drop significantly. Symptoms such as hot flushes and sleep disorders become more frequent. Postmenopause after menopause is characterised by increasingly low but more stable levels of both sex hormones. The risk of cardiovascular and bone diseases increases, and other long-term effects such as changes in the skin, mucous membranes and body composition are also typical. Experts emphasise that symptoms and levels of discomfort vary greatly from person to person in each phase. In addition, the problems usually do not persist continuously, but flare up periodically. Around a quarter of women experience severe symptoms, only mild symptoms, intermittent symptoms or no symptoms at all, says Olaf Ortmann from the University Clinic for Gynaecology and Obstetrics in Regensburg, Germany. Menopause also has a highly unpleasant characteristic, namely "the earlier the symptoms start, the longer they usually last," says Ortmann. "It can take three years – but also 15 years." Sometimes certain symptoms persist in a milder form throughout life. "Hot flushes are – extremely rarely – still possible at the age of 80." Menopause or ageing – is there a clear difference for each symptom? No. Hot flushes, associated with heavy sweating, especially at night, are considered a classic symptom related to changes in hormone levels. On average, women in the menopause experience hot flushes frequently – on more than six days within the last two weeks – for more than seven years, says the guideline "Peri- and Postmenopause – Diagnostics and Interventions" developed by professional associations in Germany. Sleep disorders, depression, mood swings, anxiety, sexual problems and joint pain are symptoms that can have various causes, but according to Schaudig, they become more frequent and intense during menopause. Gynaecologist Sheila de Liz also lists depression, anger attacks, hair loss, itchy skin or mysterious eczema, headaches, frequent bladder infections, nocturnal urinary urgency, hearing loss, weight gain and dizziness as possible menopausal symptoms in a book on the menopause. In many cases, it is not possible to say clearly what is specifically attributable to the menopause – which is ultimately also part of the natural ageing process, says Ortmann. Stress and strain in everyday life also play a major role in the severity of symptoms – and can be particularly significant for women around the age of 50. Socially disadvantaged women who are under great pressure and have little opportunity to create well-being and freedom for themselves are often severely affected, say researchers. This is consistent with studies showing that menopausal symptoms play little or no role in societies where older people are highly respected – meaning among women who tend to enjoy a high level of well-being. Will having my hormones checked provide more clarity? Not generally. During perimenopause, hormone levels fluctuate greatly – according to experts, sometimes by a factor of 20 – and therefore do not accurately reflect the status during menopause. "The various phases of the menopausal transition can be diagnosed primarily on the basis of clinical criteria," say guidelines. "Hormone testing is generally not necessary." However, Ortmann says that for certain problems such as palpitations, high blood pressure or depressive moods, it may well be useful to consider your hormone levels. Time and again, women with sleep problems are prescribed sleeping pills or those with low moods are given antidepressants, or are sent to orthopaedic surgeons or rheumatologists for joint pain – without anyone considering the possibility of the menopause. What can I do? You can alleviate symptoms through diet, exercise, mindful behaviour and targeted relaxation exercises, say experts. "There are many things you can do yourself," says Ortmann. For hot flushes, for example, lowering the room temperature in the bedroom can help. Herbal remedies are also considered helpful by many. "However, herbal remedies are not very effective if the symptoms are severe," says Ortmann. Hot flushes every few hours or weeks of sleep deprivation can be so distressing that they significantly impair quality of life and ability to work. Some women even retire earlier than planned because of this, says Schaudig. With the right hormone therapy, this can often be avoided. "The quality of life of many women is unnecessarily poor." Menopausal hormone therapy, known as MHT, is particularly effective for hot flushes and sleep problems. The term is still quite new; for decades, the treatment was known as hormone replacement therapy (HRT). The new name aims to focus more on the normal decline in hormones during the menopause and avoid the misunderstanding that hormones that should actually be present need to be replaced, Ortmann says. That would be the case say with an underactive thyroid, but not with the menopause. In Germany, oestradiol administered through the skin is predominantly used to alleviate symptoms, though treatment varies from one country to the next. Progesterone is often prescribed in capsule form as a supplement to protect the lining of the uterus from excessive growth caused by oestrogen. It can also be used to alleviate sleep disorders. Will that give me breast cancer? The widespread concern that hormone therapy significantly increases the risk of breast cancer stems, among other things, from the WHI (Women's Health Initiative) study published in 2002. The study was terminated prematurely because a slightly increased risk of breast cancer was found in one subgroup. The participants were mainly older women who had gone through the menopause and were given oral oestrogen in combination with a specific progestin. Subsequent evaluations showed that when therapy is started early – a maximum of 10 years after the menopause or at a maximum age of 60 – the ben…

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Berlin (dpa) – When inhaling cold winter air through your teeth sets off a stabbing nerve pain, you know something is wrong. For anyone with sensitive teeth, milkshakes, ice cream and just about anything cold can become a painful ordeal. As annoying as this reaction may be, it serves a purpose, says dentist Jochen Schmidt. "It’s a protective reflex of the tooth to prevent sudden temperature changes causing enamel cracks or nerve damage." There are many causes of sensitive teeth, and one common reason is receding gums, which often occurs with age. Where the gum recedes, the so-called neck of the tooth is exposed, making it easier for temperature changes to reach the tooth nerve, which then triggers a reaction. But there are other possible causes, notably thinning enamel, cavities, leaky fillings, poorly fitting crowns and an inflammation of the periodontal tissue. Schmidt says these issues can manifest as sensitivity to cold. If in doubt, it’s always best to consult a dentist. Four tips for dealing with sensitive teeth: Slow down your eating: It can help to get used to eating ice-cold food and drinks in smaller bites or sips. This helps your teeth better cope with the icy temperatures. Change your toothpaste: Toothpastes for sensitive teeth contain specific salts that can reduce the sensitivity of exposed tooth roots. Talk to your dentist:Dental practices offer various treatments for sensitive teeth, such as sealing the teeth with special varnishes. Brush gently:Brushing your teeth too hard can wear away valuable tooth enamel over time and push back the gums. An electric toothbrush with a pressure sensor that signals when you’re pressing too hard can be a helpful tool. The following information is not intended for publication dpa/tmn rid yyzz n1 nhr

(The article has been published through a syndicated feed. Except for the headline, the content has been published verbatim. Liability lies with original publisher.)